- Cdc6 Mutants
- cdc6∆2-49
- cdh1∆ cdc6∆2-49
- sic1∆ cdc6∆2-49
- sic1∆ cdc6∆2-49 cdh1∆
- sic1∆ cdc6∆2-49 cdh1∆ GALL-CDC20
- swi5∆
- swi5∆ cdh1∆
- swi5∆ cdh1∆ GAL-SIC1
- swi5∆ GAL-CLB2
- CLB2-db∆ GAL-CDC6
- CLB2-db∆ multicopy CDC6
- APC-A cdh1∆ GAL-CDC6
- APC-A cdh1∆ multicopy CDC6
- APC-A sic1∆ cdc6∆2-49
APC-A cdh1∆ multicopy CDC6
debug: ,
test user =
test db =
Simulation:
Change of parameters: ka20"=0, ksf6'=0.072, ksf6"=0.36, ksf6"'=0.012 (=3 copies), kscdh=0, init CDH1T=CDH1=0.
Experiments:
Cross, F.R. (2003). Two redundant oscillatory mechanisms in the yeast cell cycle. Dev. Cell 4:741-752.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Fig 4, rescued.
Comments: In our simulation, mass keeps increasing after each cycle and the cell eventually arrests after 5th cycle.